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Education ::
  - B.Sc. in Pharm., Pharmacy, Chulalongkorn University, 2533
  - M.Sc. in Pharm. , Pharmacognosy, Chulalongkorn University, 2536
  - Ph.D., Chemistry, University of Hawaii, 2542

Main Fields of Scientific Interests ::
  - Marine natural products; natural products synthesis; structure-activity relationship and derivatization of natural products


Fields of specialist ::
  - Organic chemistry; Organic structure determination; Organic synthesis


Research ::

  Publication ::
  1. Olatunji, O.O.; Brecker, L.; Plubrukarn, A. Metabolomics approach towards the chemical distribution in the sponge Penares cf. nux.  Songklanakarin J. Sci. Technol., 43:  696-702, 2021.
  2. Jiso, A.; Demuth, P.; Bachowsky , M.; Haas, M.; Seiwert, N.; Heylmann, D.; Rasenberger, B.; Christmann, M.;Dietrich, L; Brunner, T.; Riyanti, Schäberle, T.F.; Plubrukarn, A.; Fahrer, J. Natural merosesquiterpenes activate the DNA damage response via DNA strand break formation and trigger aApoptotic cell death in p53-wild-type and mutant colorectal cancer.  Cancers, 13:  3282, 2021.
  3. Wadeng, A; Plubrukarn, A. Tracing the stability of Andrographis Herb through 1H NMR‑based metabolomics and titrimetric approaches.  Monatsh. Chem. , 152:  569-576, 2021.
  4. Jiso, A.; Yurasakpong, L.; Janta, S.; Chaithirayanon, K.; Plubrukarn, A. Exerting DNA damaging effects of the ilimaquinones through the active hydroquinone species.  Sci. Pharm., 89:  26, 2021.
  5. Olatunji,O.O.; Petchoubon, A.; Thawai, C.; Plubrukarn, A. Allocation of trisoxazole macrolides in the sponge Penares cf. nux and the impact on epiphytic bacterial cohabitants.  Nat. Prod. Res., 34:  710-713, 2020.
  6. Jiso, A.; Kittiwisut, S.; Chantakul, R.; Yuenyongsawad, S.; Putchalkarn, S.; Scharberlle, T.; Temkitthaworn, P.; Ingkaninan, K.; Chaithirayanon, K.; Plubrukarn, A.  Quintaquinone, a Merosesquiterpene from the Yellow Sponge Verongula cf. rigida Esper.  J. Nat. Prod., 83:  532-536, 2020.
  7. Balansa, W.; Metta, U.; Wuisan, Z.G.; Plubrukarn, A.; Ijong, F.G.; Liu , Y.; Schäberle, T.F. A New Sesquiterpenoid Aminoquinone from an Indonesian Marine Sponge.  Mar. Drugs, 17:  -, 2019.
  8. Sirimangkalakitti, N.; Yokoya, M.; Chamni, S.; Chanvorachote, P.; Plubrukarn, A.; Saito, N.; Suwanborirux, K. Synthesis and absolute configuration of acanthodendrilline, a new cytotoxic bromotyrosine alkaloid from the Thai marine sponge Acanthodendrilla sp..  Chem. Pharm. Bull., 64:  258-262, 2016.
  9. Sirimangkalakitti, N.; Olatunji, O.J.; Changwichit, K.; Saesong, T.; Chamni, S.; Chanworachoote, P.; Ingkaninan, K.; Plaubrukarn, A.; Suwanborirux, K. Bromotyrosine alkaloids with acetylcholinesterase inhibitory activity from the Thai sponge Acanthodendrilla sp. .  Nat. Prod. Commun., 10:  1945-1949, 2015.
  10. Kittiwisut, S.; Rohena, C.C.; Yuenyongsawad, S.; Mooberry, S.L.; Plubrukarn, A. Antiproliferative effects of 12-oxoheteronemin vs heteronemin.  Nat. Prod. Commun., 9:  359-360, 2014.
  11. Sangnoi, Y.; Plubrukarn. A.; Arunpairojana, V.; Kanjana-Opas, A. A new antibacterial amino phenyl pyrrolidone derivative from a novel marine gliding bacterium Rapidithrix thailandica.  World J. Microbiol. Biotechnol., 30:  1135-1139, 2014.
  12. Olatunji, O.J.; Ogundajo, A.L.; Oladosu, I.A.; Changwichit, K.; Ingkaninan, K.; Yuenyongsawad, S.; Plubrukarn, A. Non-competitive inhibition of acetylcholinesterase by bromotyrosine alkaloids.  Nat. Prod. Commun. , 9:  1559-1561, 2014.
  13. Premprasert, C.; Tewtrakul, S.; Plubrukarn, A.; Wungsintaweekul, J. Anti-inflammatory activity of diterpenes from Croton stellatopilosus on LPS-induced RAW264.7 cells.  J. Nat. Med., 67:  174-181, 2013.
  14. Jaisamut, S.; Prabpai, S.; Tancharoen, C.; Hannongbua, S.; Yuenyongsawad, S.; Kongsaeree, P.; Plubrukarn, A. Bridged tricyclic sesquiterpenes from the tubercle nudibranch Phyllidia coelestis Bergh.  J. Nat. Prod., 76:  2158-2161, 2013.
  15. Yegdaneh, A.; Putchakarn, S.; Yuenyonngsawad, S.; Ghannadi, A.; Plubrukarn, A. 3-Oxoabolene and 1-oxocurcuphenol, aromatic bisabolanes from the sponge Myrmekioderma sp..  Nat. Prod. Commun., 8:  1355-1357, 2013.
  16. Sirirak, T.; Brecker, L.; Plubrukarn, A. Kabiramide L, a new antiplasmodial trisoxazole macrolide from the sponge Pachastrissa nux.  Nat. Prod. Res., 27:  1213-1219, 2013.
  17. Chanthathamrongsiri, N.; Yuenyongsawad, S.; Wattanapiromsakul, C.; Plubrukarn, A. Bifunctionalized amphilectane diterpenes from the sponge Stylissa cf. massa.  J. Nat. Prod., 75:  789-792, 2012.
  18. Pitakpornpreecha, T.; Plubrukarn, A.; Wititsuwannakul, R. Quantification of 5′‐deoxy‐5′‐methylthioadenosine in heat‐treated natural rubber latex serum.  Phytochem. Anal., 23:  12-15, 2012.
  19. Sirirak, T.; Kittiwisut, S.; Janma, C.; Yuenyongsawad, S.; Suwanborirux, K.; Plubrukarn, A. Kabiramides J and K, trisoxazole macrolides from the sponge Pachastrissa nux.  J. Nat. Prod., 74:  1288-1292, 2011.
  20. Sirirak, T.; Intaraksa, N.; Kaewsuwan, S.; Yuenyongsawad, S.; Suwanborirux, K.; Plubrukarn, A. Intracolonial allocation of trisoxazole macrolides in the sponge Pachastrissa nux.  Chem. Biodivers., 12:  2238-2246, 2011.
  21. Thengyai, S.; Maitarat, P.; Hannongbua, S.; Suwanborirux, K.; Plubrukarn, A. Probing the structural requirements for antitubercular activity of scalarane derivatives using 2D-QSAR and CoMFA approaches.  Monatsh. Chem., 141:  621-629, 2010.
  22. Wattanapiromsakul, C.; Chanthathamrongsiri, N.; Bussarawit, S.; Yuenyongsawad, S.; Plubrukarn, A.; Suwanborirux, K. 8-Isocyanoamphilecta-11(20),15-diene, a new antimalarial isonitrile diterpene from the sponge Ciocalapata sp. .  Can. J. Chem., 87:  612-618, 2009.
  23. Jaisamut, S.; Thengyai, S.; Yuenyongsawad, S.; Karalai, C.; Plubrukarn, A.; Suwanborirux, K. Structure-activity relationships of antitubercular scalaranes: Heteronemin revisited.  Pure App. Chem., 81:  1019-1026, 2009.
  24. Sangnoi, Y.; Sakulkeo, O.; Yuenyongsawad, S.; Kanjana-opas, A.; Ingkaninan, K.; Plubrukarn, A.; Suwanborirux, K. Acetylcholinesterase-inhibiting activity of pyrrole derivatives from a novel marine gliding bacterium, Rapidithrix thailandica.  Mar. Drugs, 6:  578-586, 2008.
  25. Itharat, A.; Plubrukarn, A.; Keawpradub, N.; Chuchom, T.; Ratanasuwan, P.; Houghton, P. Selective cytotoxicity and antioxidant effects of compounds from Dioscorea membranacea rhizomes.  Nat. Prod. Comm., 2:  643-648, 2007.
  26. Langjae, R.; Bussarawit, S.; Yuenyongsawad, S.; Ingkaninan, K.; Plubrukarn, A. Acetylcholinesterase-Inhibiting steroidal alkaloid from the sponge Corticium sp..  Steroids, 72:  682-685, 2007.
  27. Plubrukarn, A.; Pinsuwan, S.; Ingkatawornwong, S.; Supavita, T. Stability of andrographolide in powdered Andrographis Herb under accelerated conditions.  Planta Med., 72:  954-956, 2006.
  28. Zaeoung, S.; Plubrukarn, A.; Keawpradub, N. Cytotoxic and free radical scavenging activities of Zingiberaceous rhizomes.  Songklanakarin J. Sci. Technol., 27:  799-812, 2005.
  29. Wonganuchitmeta, S.; Yuenyongsawad, S.; Keawpradub, N.; Plubrukarn, A. Antitubercular sesterterpenes from the Thai sponge, Brachiaster sp..  J. Nat. Prod., 67:  1767-1770, 2004.
  30. Plubrukarn, A.; Yuenyongsawad, S.; Thammasaroj, T.; Jitsue, A. Cytotoxic isoquinoline quinones from the Thai sponge, Cribrochalina sp. .  Pharm. Biol. , 41:  439-442, 2003.
  31. Suwanborirux, K.; Amnuoypol, S.; Plubrukarn, A.; Pummangura, S.; Kubo, A.; Tanaka, C.; Saito, N. Chemistry of renieramycis. Part 3. Isolation and structure of stabilized renieramycin type derivatives possessing antitumor activity from Thai sponge Xestospongia species, pretreated with potassium cyanide.  J. Nat. Prod., 66:  1441-1446, 2003.
  32. Lomlim, L.; Jirayupong, N.; Plubrukarn, A. Heat-accelerated degradation of solid-state andrographolide.  Chem. Pharm. Bull., 51:  24-26, 2003.
  33. Itharat, A.; Plubrukarn, A.; Kongsaeree, P.; Bui, T.; Keawpradub, N.; Houghton, P.J. Dioscorealides and dioscoreanone, novel naphthofuranoxepins and 1,4-phenanthraquinone from Dioscorea membranacea Pierre.  Org. Lett., 5:  2879-2882, 2003.
  34. Mooberry, S.L.; Tien, G.; Hernandez, A.H.; Plubrukarn, A.; Davidson, B.S. Laulimalide and isolaulimalide, new paclitaxel-like microtubule-stabilizing agents.  Cancer Res. , 59:  653-660, 1999.
  35. Plubrukarn, A.; Davidson, B.S. Arnoamines A and B, new cytotoxic pyridoacridine alkaloids from the ascidian Cystodytes sp..  J. Org. Chem., 63:  1657-1659, 1998.
  36. Plubrukarn, A.; Smith, D.W.; Cramer, R.E.; Davidson, B.S. (2E,9E)-Pyronaamidine 9-N-(methylimine), a new imidazole alkaloid from the Northern Mariana Islands sponge Leucetta sp. cf. chagosensis.  J. Nat. Prod., 60:  712-715, 1997.
  37. ͹تԵ ¾ÅѺÃÙé¡Òà áÅÐÍÃس¾Ã ÍÔ°Ãѵ¹ì ÊÁºÑµÔ·Ò§à¤ÁÕáÅСÒÂÀÒ¾¢Í§ÊÒÃÊ¡Ñ´¤ÒÃìâºäÎà´Ãµ¨Ò¡à»Å×Í¡´éҹ㹢¹Ø¹áÅШӻҴÐ.  Ç. ʧ¢ÅÒ¹¤ÃÔ¹·Ãì, 13:  133-139, 1991.