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Education ::
  - เภสัชศาสตรบัณฑิต(เกียรตินิยมอันดับ1), เภสัชศาสตร์, มหาวิทยาลัยสงขลานครินทร์, 2530
  - เภสัชศาสตรมหาบัณฑิต, เภสัชอุตสาหกรรม, จุฬาลงกรณ์มหาวิทยาลัย, 2532
  - Doctor of Philosophy, Pharmaceutics, The school of Pharmacy, University of London, 2542

Main Fields of Scientific Interests ::
  - Formulation and Drug Delivery


Fields of specialist ::
  - Oral drug delivery systems, Formulation of Biopesticides, Polymeric drug delivery, Dendrimers


Research ::

  Publication ::
  1. Ganugula R, Arora M, Jaisamut P, Wiwattanapatapee R, Jørgensen HG, Venkatpurwar VP, et al.  Nano-curcumin safely prevents streptozotocin-induced inflammation and apoptosis in pancreatic beta cells for effective management of type 1 diabetes mellitus..  British J Pharmacol , 174:  2074-84, 2017.
  2. Petchsomrit A, Ganugula R, Wiwattanapatapee R Investigations on curcumin’s ability to enhance anticancer drug sensitivity to cancer cells..  Thai J Pharm Sci , 41:  41-44, 2017.
  3. Sangsen S, Wiwattanawongsa K, Likhitwitayawuid K, Sritularak B, Wiwattanapatapee R Comparisons between a self-microemulsifying system and lipid nanoparticles of oxyresveratrol on the physicochemical properties and Caco-2 cell permeability.  Eur J Lipid Sci Technol , 119:  1600053(1-13), 2017.
  4. Petchsomrit A, Sermkaew N, Wiwattanapatapee R Alginate-based composite sponges as gastroretentive carriers for curcumin-loaded self-microemulsifying drug delivery systems.  Sci Pharm , 85(11):  85010011(1-16), 2017.
  5. Sookkasem A, Chatpun S, Yuenyongsawad S, Sangsen Y, Wiwattanapatapee R Colon targeting of self-emulsifying and solid dispersions of curcumin using pectin beads as a delivery vehicle.  Lat Am J Pharm , 36(12):  2482-93, 2017.
  6. Chumthong A, Wiwattanapatapee R, Viernstein H, Pengnoo A. • Kanjanamaneesathian M. Spray-dried Powder of Bacillus megaterium for Control of Rice Sheath Blight Disease: Formulation Protocol and Efficacy Testing in Laboratory and Greenhouse.  Cereal Res. Commun., 44(1):  131-140, 2016.
  7. Arpa Petchsomrit, Namfa Sermkaew, Ruedeekorn Wiwattanapatapee Hydroxypropylmethyl cellulose-based sponges loaded self-microemulsifying curcumin: Preparation, characterization, and in vivo oral absorption studies..  J. Appl. Polym. Sci. , 133:  42966, 2016.
  8. Sangsen Y, Wiwattanawongsa K, Likhitwitayawuid K, Sritularak B, Graidist P, Wiwattanapatapee R Influence of surfactants in self-microemulsifying formulations on enhancing oral bioavailability of oxyresveratrol: studies in Caco-2 cells and in vivo..  Int. J. Pharm., 498:  294-303, 2016.
  9. Jaisamut P, Wiwattanawongsa K, Sangsen Y, Wiwattanapatapee R Enhanced curcumin supersaturation in gastrointestinal fluids by polymeric precipitation inhibitors.  Lat Am J Pharm , 35(4):  797-804, 2016.
  10. Sangsen Y, Wiwattanawongsa K, Likhitwitayawuid K, Sritularak B Wiwattanapatapee R Modification of oral absorption of oxyresveratrol using lipid based nanoparticles.  Colloids and Surface B: Biointerfaces, 131:  182-190, 2015.
  11. Nattha Kerdsakundee, Sirima Mahattanadul, Ruedeekorn Wiwattanapatapee Development and evaluation of gastroretentive raft forming systems incorporating curcumin-Eudragit EPO solid dispersions for gastric ulcer treatment.  Eur. J. Pharm. Biopharm, 94:  513-520, 2015.
  12. Sookkasem A, Chatpun S, Yuenyongsawad S, Wiwattanapatapee R Alginate beads for colon specific delivery of self-emulsifying curcumin.  J. Drug Deliv. Sci. Tech, 29(8):  159-166, 2015.
  13. Plyduang T, Lomlim L, Yuenyongsawad S, Wiwattanapatapee R Carboxymethylcellulose-tetrahydrocurcumin conjugates for colon-specific delivery of a novel anti-cancer agent, 4-amino tetrahydrocurcumin.  Eur. J. Pharm. Biopharm., 88(2):  351-360, 2014.
  14. Sermkaew N, Ketjinda W, Boonme P, Padoongsombat N and Wiwattanapatapee R  Liquid and solid self-microemulsifying drug delivery systems for improving the oral bioavailability of andrographolide from a crude extract of Andrographis paniculata.  European J. Pharm. Sci., 50 (3-4):  459-466, 2013.
  15. Jutharat Khochchawech, Chutima Tantikitti, Ruedeekorn Wiwattanapatapee  Effects of forms of weaning diets on acceptability, survival rate and growth in early juvenile Asian seabass (Lates calcarifer, Bloch).  Thai Fisheries Gazette, 66:  29-39, 2013.
  16. Sermkaew N, Wiwattanawongsa K, Kedjinda W and Wiwattanapatapee R Development, characterization and permeability assessment based on Caco-2 monolayers of self-microemulsifying floating tablets of tetrahydrocurcumin .  AAPS PharmSciTech, 14 (1):  321-331, 2013.
  17. Wiwattanapatapee R, Chumthong A, Pengnoo A, and Kanjanamaneesathian M Preparation and evaluation of Bacillus megaterium-alginate microcapsules for control of rice sheath blight disease .  World J. Microbiol. Biotech., 29:  1487-1497, 2013.
  18. Sangsen Y, Likhitwitayawuid K, Sritularak B, Wiwattanawongsa K, Wiwattanapatapee R Novel Solid Lipid Nanoparticles for Oral Delivery of Oxyresveratrol: Effect of the Formulation Parameters on the Physicochemical Properties and in vitro Release.  International Journal of Medical, Pharaceutical Science and Engineering , 7 (12):  873-880, 2013.
  19. Petchsomrit A, Sermkaew N , Wiwattanapatapee R Effect of Alginate and Surfactant on Physical Properties of Oil Entrapped Alginate Bead Formulation of Curcumin.  International Journal of Medical, Pharmaceutical Science and Engineering , 7 (12):  479-483, 2013.
  20. Jaisamut P, Wiwattanawongsa K, Wiwattanapatapee R  Influence of Natural Gum on Curcumin Supersaturation in Gastrointestinal Fluids .  International Journal of Medical, Pharmaceutical Science and Engineering, 7 (12):  631-634, 2013.
  21. Sriraksa S, Sermkaew N, Setthacheewakul S and Wiwattanapatapee R Floating Alginate Beads as Carriers for Self-Emulsifying System Containing Tetrahydrocurcumin.  Adv. Mater. Res., 506:  517-520, 2012.
  22. Setthacheewakul S, Kedjinda W, Maneenuan D and Wiwattanapatapee R Controlled release of oral tetrahydrocurcumin from a novel self-emulsifying floating drug delivery system (SEFDDS) .  AAPS PharmSciTech., 12:  152-164, 2011.
  23. Setthacheewakul S, Mahattanadul S, Padoongsombat N, Pichayakorn W and Wiwattanapatapee R Development and evaluation of self-microemulsifying liquid and pellet formulations of curcumin, and absorption studies in rat.  Eur. J. Pharm. Biopharm., 76:  475-485, 2010.
  24. M. Kanjanamaneesathian, A. Chumthong, A. Pengnoo and R. Wiwattanapatapee Bacillus megaterium suppresses major thai rice diseases.  Asian Journal of Food & Agro-Industry, 2 (August):  s154-s159, 2009.
  25. ณัฐวดี สมบัติเทพสุทธิ์ ฤดีกร วิวัฒนปฐพี สนั่น ศุภธีรสกุล และสุนทร พิพิธแสงจันทร์  การขับไล่และลดการวางไข่ของสารสกัดหยาบจากรากของหนอนตายหยาก โล่ติ๊น และน้ำมันเมล็ดสะเดาช้างที่มีต่อผีเสื้อหนอนใยผัก .  วารสารวิชาการเกษตร, 27(2):  170-183, 2009.
  26. Wiwattanapatapee R, Sae-Yun A, Petcharat J, Ovartlarnporn C , Itharat, A Development and Evaluation of Granule and Emulsifiable Concentrate Formulations containing Derris elliptica Extract for Crop Pest Control.  Journal of Agricultural and Food Chemistry , 57:  11234-11241, 2009.
  27. Treetharnmathurot B, Dieudonne L, Ferguson EL, Schmaljohann D, Duncan R, Wiwattanapatapee R Dextrin-trypsin and ST-HPMA-trypsin conjugates: Enzyme activity, autolysis and thermal stability.  Int. J. Pharm., 373:  68-76, 2009.
  28. Treetharnmathurot B, Ovartlarnporn C, Wungsintaweekul J, Duncan R and Wiwattanapatapee R Effect of PEG molecular weight and linking chemistry on the biological activity and thermal stability of PEGylated trypsin.  Int. J. Pharm., 357 (1-2):  252-259, 2008.
  29. Pureesatien O, Ovatlarnporn O, Itharat A, Wiwattanapatapee R Quantitative HPLC Determination and Stability of Pyrido[1,2a]azepine Alkaloid, Pesticidal Compound in the Extract of Stemona curtisii and Water Dispersible Granules.  Chromatographia, 67 (7-8):  551-557, 2008.
  30. Chumthong A, Kanjanamaneesathian M, Pengnoo A, Wiwattanapatapee R Water-soluble granules containing Bacillus megaterium for biological control of rice sheath blight: Formulation, bacterial viability and efficacy testing .  World J. Microbiol. Biotech., 24 (11):  2499-2507, 2008.
  31. Hnoomak, Pengnoo A, Wiwattanapatapee R and Kanjanamaneesathian M In vitro testing of Bacillus megaterium against soil-borne fungal pathogen.  Naresuan agricultural journal, 11 (Suppl.):  167-173, 2008.
  32. Kanjanamaneesathian M, Wiwattanapatapee R, Pengnoo A , Oungbho K and Chumthong A Efficacy of novel formulations of Bacillus megaterium in suppressing sheath blight of rice caused by Rhizoctonia salani.  Plant Pathology Journal, 6:  195-201, 2007.
  33. Wiwattanapatapee R, Chumthong A, Pengnoo A and Kanjanamaneesathian M Effervescent fast-disintegrating bacterial formulation for biological control of rice sheath blight .  J. Controlled Release, 119:  229-235, 2007.
  34. Pengnoo A, Wiwatanapatapee R, Chumthong A, Kanjanamaneesathian M Bacterial antagonist as seed treatment to control leaf blight disease of bambara groundnut (Vigna subterranea).  World J Microbiol. Biotech., 22:  9-14, 2006.
  35. Sae-Yun A, Ovatlarnporn A, Itharat A, Wiwattanapatapee R Extraction of rotenone from Derris elliptica and Derris malaccensis by pressurized liquid extraction compared with maceration.  J. Chromatography A, 1125(2):  172-176, 2006.
  36. Pengnoo A, Wiwatanapatapee R, Chumthong A, Rotniam W and Kanjanamaneesathian M Preliminary study on the effect of culture medium on the number and size of endospores of Bacillus megaterium.  Silpakorn University Science and Technology Journal, 5:  129-139, 2005.
  37. Wiwattanapatapee R, Pengnoo A, Kanjanamaneesathian M, Matchavanich, W, Nilratana, L and Jantharangsri Floating pellets containing bacterial antagonist for control sheath blight of rice: Formulation, viability and bacterial release studies.  J. Controlled Release, 95(3):  453-460, 2004.
  38. Wiwattanapatapee R, Lomlim L and Saramunee K Dendrimers conjugates for colonic delivery of 5-aminosalicylic acid .  J. Controlled Release, 88:  1-9, 2003.
  39. Wiwattanapatapee R., Padoongsombat N., Choochom T., Tang S. and Chaimongkol A. Water flea Moina macrocopa as a novel biocarrier of norfloxacin in aquaculture .  J. Controlled Release, 83 (1):  23-28, 2002.
  40. Wiwattanapatapee R, Srichana T, Maneenuan D and Chaimongkol A Bioencapsulation of sulfamethoxazole and trimethoprim in a novel live drug carrier: water flea Moina macrocopa.  Thai J. Pharm. Sci., 25 (suppl):  15, 2001.
  41. Wiwattanapatapee R and Srichana T Development of sulphamethoxazole/trimethoprim floating pellets.  Songklanakarin J. Sci. Tech., 23(4):  593-598, 2001.
  42. Malik N, Wiwattanapatapee R, Klopsch R, Lorenz K, Frey H, Weener JW, Meijer EW, Paulus W and Duncan R Dendrimers: Relationship between structure and biocompatibility in vitro, and preliminary studies on the biodistribution of 125I-labelled PAMAM dendrimers in vivo.  J. Control. Rel., 65:  133-148, 2000.
  43. R. Wiwattanapatapee and R. Duncan Polyamidoamine dendrimers as a novel oral drug delivery system: Synthesis and characterisation of dendrimer-ibuprofen conjugates.  Thai. J. Pharm. Sci. , 24 (suppl):  67, 2000.
  44. R. Wiwattanapatapee, B. Carreno-Gomez, N. Malik, R. Duncan Anionic PAMAM dendrimers rapidly cross adult rat intestine in vitro: A potential oral delivery system.  Pharm. Res., 17(8):  991-998, 2000.
  45. Wiwattanapatapee R, Carreno-Gomez B, Malik N and Duncan R,  PAMAM dendrimers as a potential oral drug delivery system: uptake to the rat intestine in vitro.  J. Pharm. Pharmacol. , , 50 (suppl):  99, 1998.
  46. Wiwattanapatapee R, Paulus W and Duncan R,  Preliminary biological evaluation of polyaminodendrimers.  J. Pharm. Pharmacol. , 49 (suppl):  28 , 1997.
  47. Wiwattanapatapee, R, and Pinsuwan, S.  The Stability of Freeze Dried Aloe Vera Powdered With Various Diluent. .  Songklanakarin J. Sci. Technol,, 15(2):  159-166, 1993.