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Education ::
  - »ÃÔ­­ÒµÃÕ, Pharmacy, Chulalongkorn University, 2533
  - »ÃÔ­­Òâ·, Pharmaceutical Chemistry (Medicinal Chemistry), Chulalongkorn University, 2536
  - Ph. D., Pharmaceutical Chemistry, Welsh School of Pharmacy, University of Wales, College of Cardiff, 2540

Main Fields of Scientific Interests ::
  - Pharmaceutics & Drug Delivery Research; Molecular Recognition Materials; Chiral Separation
  - Reseach Interest:
1. Pharmaceutics & Drug Delivery Research
2. Molecular Recognition Materials

Co-ordinator: Assoc. Prof. Dr. Roongnapa Srichana(MRMs Research Team)

Research overview

The Molecular Recognition Materials Research has been successful in the development of related applications of molecular recognition processes involving a range of molecular imprinting techniques. This technique involves arranging functional monomers around a templating ligand. This ligand is the selected target substance (such as drugs, pesticides, amino acids, nucleic acids, enzymes and cells), and it forms a pre-polymerization complex with the monomer by non-covalent interactions, such as hydrogen bonding, ionic or hydrophobic interaction. The complexes formed are subsequently co-polymerized with a suitable cross-linking monomer and the imprint molecule removed from the polymer to yield recognition sites specific to the original templates. The resulting molecularly imprinted polymer or so called “MIP” can selectively recognize and rebind the template molecule or even bind with other closely related molecules. These new materials have a vast number of application areas including analytical chemistry, separations, sensors, synthesis catalysis and material sciences.
We have been particularly successful in development of novel pharmaceutical and related applications of molecular recognition materials processes involving a range of imprinting techniques, including use in drug delivery, transdermal monitoring, sensor technology, and separation of individual compound from complex mixtures. Currently, the group includes 1-2 under-graduate elective students for each year, 2 master degree students and 3 PhD students. The work is supported by university, government and research council sources (e.g. Thailand Research Fund).

Collaboration

Prof. Gary Martin, King’s College, University of London, London, UK.
Prof. Franz L. Dickert, Institute of Analytical Chemistry, University of Vienna, Vienna, Austria
Prof. Wolfgang Lindner, Institute of Analytical chemistry, University of Vienna, Vienna, Austria
 Prof. Helmut Viernstein
Department of Pharmaceutical Technology and Biopharmaceutics, Vienna, Austria
Assist. Prof. Dr. Pikul Vanichapichat, Biophysics Team, Membrane Science and Technology Research Center, Prince of Songkla University

Relevant publications

1. Sontimuang, C., Suedee R., Canyuk B., Phadungsombut N., Dickert F. L., Development of a rubber elongation factor, surface-imprinted polymer-quartz crystal microbalance sensor, for quantitative determination of Hev b1 rubber latex allergens present in natural rubber latex products, Anal. Chim. Acta 687 (2011) 184-192. (Impact factor = 3.72)

2. Sontimuang, C., Suedee R., Dickert F.L., Interdigitated capacitive biosensor based on molecularly imprinted polymer for rapid detection of Hev b1 latex allergen, Anal. Biochem. 410 (2011) 224-233. (Impact factor =3.2)

3. Suedee, R., Jantarat, C., Lindner, W., Viernstein, H., Songkro, S. and Srichana, T. 2010. Development of a pH-responsive drug delivery system for enantioselective-controlled delivery of racemic drugs. J. Control. Release 142: 122-131. (Impact factor =7.1)

4. Suedee, R., Bodhibukkana, C., Tangthong, N., Amnuaikit, C., Kaewnopparat, S., Srichana, T. 2008. Development of a reservoir-type transdermal enantioselective-controlled delivery system for racemic propranolol using a molecularly imprinted polymer composite membrane. J. Control. Release 129: 170-178. (Impact factor =7.1)

5. Suedee, R., Seechamnanturakit, V., Suksuwan, A. and Canyuk, B. 2008. Recognition properties and competitive assays of a dual dopamine/serotonin selective molecularly imprinted polymer. Int. J. Mol. Sci. 9: 2333-2356. (Impact factor = 2.279)

6. Jantarat, C., Tangthong, N., Songkro, S., Martin, G.P. and Suedee, R. 2008. S-propranolol imprinted polymer nanoparticle-on-microsphere composite porous cellulose membrane for enantioselectively controlled delivery of racemic propranolol. Int. J. Pharm. 349: 212-225. (Impact factor =3.607)

7. Suedee, R., Seechamnanturakit, V., Canyuk, B., Ovatlarnporn, C. and Martin, G.P. 2006. Temperature sensitive dopamine-imprinted (N,N-methylene-bis-acrylamide cross-linked) polymer and its potential application to the selective extraction of adrenergic drugs from urine. J. Chromatogr. A 1114: 239-249. (Impact factor =4.010)

8. Bohdhibukkana, C., Srichana, T., Kaewnopparat, S., Tangthong, N., Martin, G.P and Suedee, R. 2006. Composite membrane of bacterially-derived cellulose and molecularly imprinted polymer for use as a transdermal enantioselective controlled-release system of racemic propranolol. J. Control. Release 113: 43-56. (Impact factor =7.1)


Contact address:
Department of Pharmaceutical Chemistry
Faculty of Pharmaceutical Sciences
Prince of Songkla University
Hatyai, Songkla 90112 Thailand
Tel: 66 74 288862,
mobile phone: 081 957 5407
Fax: 66 74 428239
E-mail address: roongnapa.s@psu.ac.th


Fields of specialist ::
  - Imprinted Polymers; Chiral Separation; Pharmaceutics & Drug Delivery Research
  - Molecular Recognition Materials Research Unit

Overview:
Molecular imprinting is an efficient method for introducing specific molecular recognition sites into a polymeric matrix. The technique by which molecularly imprinted polymers (MIPs) are produced involves arranging functional monomers around a templating ligand. This ligand is the selected target substance, e.g., a drug, enantiomer, or toxic substance. The ligand forms a pre-polymerization complex with the monomer by non-covalent interactions, such as hydrogen bonding, ionic or hydrophobic interaction, pi-pi interaction, or charge transfer. The complexes formed are subsequently co-polymerized with a suitable cross-linking monomer, and the imprint molecule removed by washing to yield a polymer matrix containing randomly imprinted cavities that can selectively recognize and re-bind the imprinted ligand or other molecules similar in structure to the original print molecule. This technique has found numerous applications, such as new stationary phases for chromatographic separations – especially resolution of enantiomeric mixtures. Other uses have also been found for MIPs: in immunoassay-like analyses, as synthetic enzyme-mimics, as sensors, as tools for studying molecular recognition receptors, and increasingly in the design of drug delivery systems.

Pharmaceutics & Novel Drug Delivery Research:

Recently, newer applications of molecularly imprinted polymers have also been described: for use in developing enantioselective-controlled drug delivery systems for chiral pharmaceutical substances. The design, synthesis, characterization and evaluation of MIPs are the basis of these studies which have produced proven materials suitable for various applications. A specific application of MIP materials has been discovered for use in controlled drug delivery of enantiomer of racemic drugs. The use of this synthesized MIP recognition material in enantioselective-controlled drug delivery systems as membranes, composites and beads for chiral pharmaceutical substances has been particularly successful.
Other applications of MIP-based polymer materials which have been investigated by our research group are in the areas of sensors and separation techniques (for example ; as sensing materials for complex mixtures of haloacetic acids, the carcinogenic substances found in drinking water; for developing new tools for more efficient extraction and separation of substances from complex mixtures; and for screening dopamine/serotonin binding sites of ergot-related compounds. These applications of MIP-based materials involve chromatography and solid-phase extraction for determining the enantiomeric purity of bulk drug substances, and particularly the use of techniques for the preparation of novel materials for use in solid-phase extraction of pharmaceutical residues and toxic impurities. The research has been further extended to the extraction of analytes from mammalian biological samples and direct extraction by MIPs of active compounds from plant samples. The application of stimuli-resonive MIP materials for screening the ligands of natural receptors (such as dopamine and serotonin) has also been investigated.
The investigation of the design and preparation of MIP materials as sensing elements and their use in inter-digital conductometric and mass measurement for detecting haloacetic acids and protein allergens has been successfully conducted.


National & International Collaborations:

We collaborates, both nationally and internationally, with more than ten research scientists. Our group has received more than 20 research grants from either universities or granting agencies within or outside the country (e.g. Prince of Songkla University, the Thailand Research Fund, and the National Research Council of Thailand; and foreign financial support from ASEA-UNINET, and the University of Vienna, Austria). Five exchange Ph.D. students have been sent to the Department of Pharmacy, King’s College London, UK; and to the Department of Analytical Chemistry and Food Chemistry and the Department of Pharmaceutical Technology and Biopharmaceutics, University of Vienna. The applicant’s research has made an important contribution to basic and applied science in this research field.


Research ::

  Publication ::
  1. Sreenu Madhumanchi, Ramana Jadda, Roongnapa Suedee Efficient adsorptive extraction materials by surface protein-imprinted polymer over silica gel for selective recognition/separation of human serum albumin from urine.  Journal of Applied Polymer Sciences, 135:  46894(p1-13), 2018.
  2. Supannika Klangphukhiew, Roongnapa Srichana and Rina Patramanon  Cortisol Stress Biosensor Based on Molecular Imprinted Polymer.  Proceedings, 1 (538):  1-4, 2017.
  3. Suticha Chunta, Sanita Singsanan, Roongnapa Suedee, Peter A. Lieberzeit  Based on Molecularly Imprinted Polymers for Simultaneous Detection of Lipoproteins.  Proceedings, 1(538):  1-5, 2017.
  4. Pijush Kumar Paul, Jongdee Nopparat, Mitree Nuanplub, Alongkot Treetong and Roongnapa Suedee Improvement in insulin absorption into gastrointestinal epithelial.  Int. J. Pharm., 279(1-2):  279-290, 2017.
  5. Chunta, S., Suedee R., Lieberzeit, P.A. High-density lipoproteinsensor based on molecularly imprinted polymer.  Anal. Bioanal. Chem., online ISSN 1618-2642:  1-10, 2017.
  6. Pijush K. Paul, Alongkot Treetong, Roongnapa Suedee Biomimetic insulin-imprinted polymer nanoparticles as a potential oral drug delivery system.  Acta Pharm., 67:  149–168, 2017.
  7. WanpenNaklua, RoongnapaSuedee, PeterA.Lieberzeit Dopaminergic receptor–ligand bindingassaysbasedonmolecularly imprintedpolymersonquartzcrystalmicrobalancesensors.  Biosensors andBioelectronics, 81:  117–124, 2016.
  8. Chunta S., Suedee R., Lieberzeit P.A Low-density lipoprotein sensor based on molecularly imprinted polymer.  Anal. Chem., 88 :  1419–1425, 2016.
  9. Naklua W., Mahesh K., Chen Y.Z., Chen Shangying C., Roongnapa S.  Molecularly imprinted polymer microprobes for manipulating neurological function by regulating temperature-dependent molecular interactions. .  Process Biochemistry, 51 :  142-157, 2016.
  10. Suksuwan A., Lomlim L., Rungrotmongkol T., Nakpheng T., Dickert L. F., Suedee R. The composite nanomaterials containing (R)-thalidomide-molecularly imprinted polymers as a recognition system for enantioselective controlled release and targeted drug delivery. .  J. Appl. Pol. Sci., 132:  41930 (p 1-21), 2015.
  11. Suedee R., Naklua W., Laengchokshoi S., Thepkaue K., Pathaburee P., Nuanplub M. Investigation of a self-assembling microgel containing an (S)-propranolol molecularly imprinted polymer in a native tissue microenvironment: Part I preparation and characterization. .  Process Biochemistry, 50:  517-531., 2015.
  12. Suedee R., Naklua W., Laengchokshoi S., Thepkaue K., Pathaburee P., Nuanplub M.  Investigation of a self-assembling microgel containing an (S)-propranolol molecularly imprinted polymer in a native tissue microenvironment: Part II biological application and testing.  Process Biochemitrsy,  50:  532-544., 2015.
  13. Suksuwan A., Lomlim L., Dickert L. F., Suedee R.,  Tracking the chemical surface properties of racemic thalidomide and its enantiomers using a biomimetic functional surface on a quartz crystal microbalance. .  J. Appl. Pol. Sci., 132:  42309(1-14), 2015.
  14. Naklua W., Mahesh K., Aundorn P., Tanmanee N., Aenukulpong K., Sutto S. Chen Y.Z., Chen S., Suedee R.  An imprinted dopamine receptor for discovery of highly potent and selective D3 analogues with neuroprotective effects. .  Process Biochemistry, 50:  1537-1556, 2015.
  15. Lily Jaiswal, Sirirat Rakkit, Kristda Pochin, Punyavit Jaisamut, Chanpa Tanthana,Niwan Tanmanee, Teerapol Srichana, Roongnapa Suedee A thalidomide templated molecularly imprinted polymer thatpromotes a biologically active chiral entity tagged in colon carcinomacells and protein-related immune activation.  Process Biochemistry , 50:  2035–2050, 2015.
  16. Suedee R,  The use of molecularly imprinted polymers for dermal drug delivery, .  Pharm Anal Acta , 4 (8):  1-23, 2013.
  17. Suedee R. Novel strategic innovations for designing drug delivery system using molecularly imprinted micro/nanobeads.  Int. J. Pharm. Sci. Rev. Res. , 20 (2):  235-268, 2013.
  18. Seechamnanturakit, V., Suedee, R.  The synthesis and characterization of retinol-molecularly imprinted polymers as a selective sorbent in solid-phase extraction.  Int. J. Appl. Sci. Tech. , 2 :  81-93., 2012.
  19. Chonlatid Sontimuang, Roongnapa Suedee, Franz Dickert Interdigitated capacitive biosensor based on molecularly imprinted polymer for rapid detection of Hev b1-latex allergen.  Analytical Biochemistry, 410:  224-233, 2011.
  20. Chonlatid Sontimuang, Roongnapa Suedee, Bhutorn Canyuk, Narubodee Phadoongsombut, Franz L. Dickert Development of a rubber elongation factor, surface-imprinted polymer-quartz crystal microbalance sensor, for quantitative determination of Hev b1 rubber latex allergens present in natural rubber latex products.  Analytica Chimica Acta, 687:  184-192, 2011.
  21. 4. Dickert, F.L., Lieberzeit, P., Schirhagl, R., Aigner, S., Sontimuang, C., Suedee, R.,  Blumenstock, Biorekognition mit strukturierton Oberflächen-Sensoranwendungen zur insulin-und allergendetektion. .  Sensoren Messsysteme , 18 :  68-73, 2010.
  22. Roongnpa Suedee, Chutima Jantarat, Wolfgang Lindner, Helmut Viernstein, Sarunyoo Songkro, and Teerapol Srichana  Development of a pH-responsive drug delivery system for enantioselective-controlled delivery of racemic drugs.  J. Contr. Rel., 142:  122-131, 2010.
  23. Chutima Jantarat, Naruedom Tangthong, Sarunyoo Songkro, Gary P. Martin and Roongnapa Suedee S-propranolol imprinted polymer nanoparticle-on-microsphere composite porous cellulose membrane for the enantioselectively controlled delivery of racemic propranolol.  Int. J. Pharm., 349:  212-225, 2008.
  24. Roongnapa Suedee, Vatcharee Seechamnanturakit, Acharee Suksuwan and Bhutorn Canyuk  Recognition Properties and Competitive Assays of a Dual Dopamine/Serotonin Selective Molecularly Imprinted Polymer .  International Journal of Molecular Sciences, 9:  2333-2356, 2008.
  25. Roongnapa Suedee, Chatchada Bodhibukkana, Naruedom Tangthong, Chomchan Amnuaikit, Sanae Kaewnopparat, Teerapol Srichana Development of a reservoir-type transdermal enantioselective-controlled delivery system for racemic propranolol using a molecularly imprinted polymer composite membrane.  Journal of Controlled Release, 129:  170-178, 2008.
  26. Roongnapa Suedee , Wimon Intakong , Peter A. Lieberzeit , Pikul Wanichapichart , Pipat Chooto d and Franz L. Dickert  Trichloroacetic acid-imprinted polypyrrole film and its property in piezoelectric quartz crystal microbalance and electrochemical sensors to application for determination of haloacetic acid disinfection by-product in drinking water.  J. Appl. Pol. Sci, 106:  3861-3871, 2007.
  27. Zikant Saenkasa, Chaiyavat Chaiyasut, Roongnapa Srichana, Sirivipa Piyamongkol Comparison of molecular adsorption ability of the molecularly imprinted polymers prepared by ethylene glycol dimethacrylate and trimethylolpropane trimethacrylate as cross linkers.  Journal of Applied Polymer Science, 103:  2325-2330, 2007.
  28. R. Suedee, V. Seechamnanturakit, B. Canyuk, C. Ovatlarnporn, G.P. Martin, Temperature sensitive dopamine-imprinted (N,N-methylene-bis-acrylamide cross-linked) polymer and its potential application to the selective extraction of adrenergic drugs from urine.  J. Chromatogr. A, 1114:  239-249, 2006.
  29. C. Bohdhibukkana, T. Srichana, S. Kaewnopparat, N. Tangthong, G.P. Martin, R. Suedee, Composite membrane of bacterially-derived cellulose and molecularly imprinted polymer for use as a transdermal enantioselective controlled-release system of racemic propranolol.  J. Contr. Rel., 113:  43-56, 2006.
  30. R. Suedee, W. Intakong, F.L. Dickert Molecularly imprinted polymer-modified electrode for on-line conductometric monitoring of haloacetic acids in drinking water.  Anal. Chim. Acta, 569:  66-75, 2006.
  31. R. Suedee, W. Intakong, F.L. Dickert The use of Trichloroacetic acid imprinted polymer coated quartz crystal microbalance as a screening method for determination of haloacetic acids in drinking water.  Talanta, 70:  194-201, 2006.
  32. Srichana, T., Suedee, R., Muanpanarai, D. and Tanmanee, N.  The study of in vitro- in vivo correlation: pharmacokinetics and pharmacodynamics of albuterol dry powder inhalers. .  J.Pharm.Sci., 94:  220-230, 2005.
  33. Suedee, R., Srichana, T., Chuchome ,T. and Kongmark, U. Molecularly imprinted polymers from a mixture of tetracycline and its degradation products, to produce affinity membranes for the removal of tetracycline from water .  J. Chromatogr. B, 811:  191-200, 2004.
  34. Suedee, R., Srichana T., Sangpagai T., Tunthana C. and Vanichapichat P. Development of trichloroacetic acid sensor based on molecularly imprinted polymer membrane for the screening of combinatorial mixture of haloacetic acids in drinking water.  Anal. Chim. Acta, 504:  89-100, 2004.
  35. Srichana, T., Suedee, R. and Srisudjai, P.  The application of spectrofluorometry for evaluation of dry powder inhalers in vitro .  Pharmazie, 58:  125-129, 2003.
  36. Suedee, R., Srichana, T., Chotivatesin, R. and Martin, G.P. Stereoselective release behaviors of imprinted bead matrices.  Drug Dev. Ind. Pharm., 28(5):  545-554, 2002.
  37. Suedee, R., Srichana, T. and Rattananont, T. Enantioselective release of controlled delivery granules based on molecularly imprinted polymers.  Drug delivery, 9(1):  19-30, 2002.
  38. Srichana, T. and Suedee, R. Evaluation of stereoselective dissolution of racemic salbutamol matrices prepared with commonly used excipients and proton NMR study .  Drug Dev. Ind. Pharm., 27(5):  457-464, 2001.
  39. Suedee, R., Srichana, T., Saelim, J. and Thavornpibulbut, T. Thin-layer chromatographic separation of chiral drugs on molecularly imprinted chiral stationary phases.  J. Planar Chromatogr.-Modern TLC, 14:  194-198, 2001.
  40. Srichana, T., Suedee, R. and Reanmongkol, W. Cyclodextrin as a potential drug carrier in salbutamol dry powder aerosols: The in vitro deposit and toxicity studies of the complexes.  Respir. Med., 95(6):  513-519, 2001.
  41. Srichana, T. and Suedee, R. Enantioselective separation of salbutamol from spiked urine extracted with solid stationary phase.  Thai J.Pharm.Sci., 24(1):  27-36, 2000.
  42. Suedee, R., Srichana, T., and Martin, G.P. Evaluation of matrices containing molecularly imprinted polymers in the enantioselective-controlled delivery of b-blockers.  J. Contr. Rel., 66(2-3):  135-147, 2000.
  43. Suedee, R. Songkram, C., Petmoreekul, A., Sangkunakup, S. ,Sankasa, S., and Kongyarit, N. Direct enantioseparation of adrenergic drugs via thin-layer chromatography using molecularly imprinted polymers.  J. Pharm. Biomed. Anal., 19:  519-527, 1999.
  44. Suedee, R., Srichana, T.,Saelim, J., and Thavornpibulbut, T. Chiral determination of various adrenergic drugs by thin-layer chromatohraphy using molecularly imprinted chiral stationary phase prepared with a-agonists.  Analyst, 124(7):  1003-1009, 1999.
  45. Suedee, R., Brain, K.R. and Heard C.M. Differential permeation of propranolol enantiomers across human skin in vitro from formulation containing an enantioselective excipient.  Chirality, 11:  680-683 (Thesis), 1999.
  46. Srichana, T. and Suedee, R.  Chiral liquid membrane containing a dipentyl-beta-cyclodextrin: Enantioselective partition of racemic pseudoephedrine.  Thai J.Pharm.Sci., 23:  187-196, 1999.
  47. Suedee, R., Songkram, C., Petmoreekul, A., Sangkunakup, S., Sankasa, S. and Kongyarit, N. Thin-layer chromatography using synthetic polymers imprinted with quinine as chiral stationary phase.  J. Planar Chromatogr-Modern TLC, 11:  272-276, 1998.
  48. Heard, C.M., Brain, K.R., Nicholls, P.J. and Suedee, R. Differential permeation of propranolol enantiomers across human skin in-vitro as a result of stereoselective sorption/desorption.  J. Pharm. Pharmaco., 49 (Suppl. 4):  27 (Thesis), 1997.
  49. Suedee, R. and Heard, C.M. Direct resolution of propranolol and bupranolol by thin-layer chromatography using cellulose derivatives as stationary phase.  Chirality, 9:  139-144 (Thesis), 1997.
  50. Suedee, R., Brain, K.R. and Heard, C.M. Enantioselective retardation of rac-propranolol from matrices containing cellulose derivatives.  Chirality, 9:  307-312 (Thesis), 1997.
  51. Heard, C.M. and Suedee, R. Stereoselective adsorption and trans-membrane transfer for propranolol enantiomers using cellulose derivatives.  Int. J. Pharm., 139:  15-23 (Thesis), 1996.