:: Last Update ::

Pharkphoom  Panichayupakaranant

Tel No ::  074-288980
E-mail Address ::  pharkphoom.p@psu.ac.th
Homepage ::  pcog.pharmacy.psu.ac.th

Education ::
  - Bachelor 's degree , Pharmacy, Prince of Songkla University, 2532
  - Master 's degree , Pharmacognosy, Chulalongkorn University, 2535
  - Doctorate, Pharmaceutical Chemistry and Natural Products, Chulalongkorn University, 2540

Main Fields of Scientific Interests ::
  - Antimicrobial activity of Thai medicinal plants, Bioassay-guided isolation of the active compound, Establishment of HPLC quantitative analysis method for standardization of the herbal extracts, Preparation of active compound rich herbal extracts and Increasing of secondary metabolite production by plant tissue culture techniques

Fields of specialist ::
  - Natural Product Chemistry and Plant Tissue Cultures

Research ::

  Publication ::
  1. Chen, Z., Li, W., Guo, Q., Xu, L., Santhanam, R. K., Gao, X., Chen, Y., Wang, C., Panichayupakaranant, P. and Chen, H.  Anthocyanins from dietary black soybean potentiate glucose uptake in L6 rat skeletal muscle cells via up-regulating phosphorylated Akt and GLUT4.  Journal of Functional Foods , 52:  663-669, 2019.
  2. Septama, A.W., Panichayupakaranant, P. Artocarpin isolated from Artocarpus heterophyllus heartwoods alters membrane permeability of Streptococcus mutans.  Journal of Applied Pharmaceutical Science, 8:  59-64, 2018.
  3. Promsong, A., Chuenchitra, T., Saipin, K., Tewtrakul, S., Panichayupakaranant, P., Satthakarn, S., Nittayananta, W. Ellagic acid inhibits HIV-1 infection in vitro: Potential role as a novel microbicide.  Oral Diseases , 24:  249-252, 2018.
  4. Shah, M.A. Keach, J.E. and Panichayupakaranant, P.  Antidiabetic naphthoquinones and their plant resources in Thailand.  Chemical and Pharmaceutical Bulletin , 66:  483-492, 2018.
  5. Septama, A.W., Jantan, I. and Panichayupakaranant, P. Flavonoids of Artocarpus heterophyllus Lam. heartwood inhibit the innate immune responses of human phagocytes.  Journal of Pharmacy and Pharmacology, 70:  1242-1252, 2018.
  6. Suedee, A., Tewtrakul, S. and Panichayupakaranant, P. A validated quantitative HPLC method for proanthocyanidin A2 in Pometia pinnata leaves.  Global Journal of Botanical Science, 5:  9-15, 2017.
  7. Jaisi, A. and Panichayupakaranant, P.  Enhanced plumbagin production in Plumbago indica root cultures by L-alanine feeding and in situ adsorption.  Plant Cell, Tissue and Organ Culture, 129:  53-60, 2017.
  8. Boonruamkaew, P, Sukketsiri, W, Panichayupakaranant, P., Kaewnam, W., Tanasawet, S., Tipmanee, V., Hutamekalin, P. and Chonpathompikunlert, P. Apium graveolens extract influences mood and cognition in healthy mice.  Journal of Natural Medicines, 71:  492–505, 2017.
  9. Septama, A.W. Xiao, J. and Panichayupakaranant, P. A synergistic effect of artocarpanone from Artocarpus heterophyllus L. (Moraceae) on the antibacterial activity of selected antibiotics and cell membrane permeability.  Journal of Intercultural Ethnopharmacology, 6:  186-191, 2017.
  10. Jaisi, A. and Panichayupakaranant, P. Chitosan elicitation and sequential Diaion®HP-20 addition a powerful approach for enhanced plumbagin production in Plumbago indica root cultures.  Process Biochemistry , 53:  210-215, 2017.
  11. Sakunpak, A., Matsunami, K., Otsuka, H. and Panichayupakaranant, P.  Isolation of chamuangone, a cytotoxic compound against Leishmania major and cancer cells from Garcinia cowa leaves and its HPLC quantitative determination method.  Journal of Cancer Research Updates , 6:  38-45, 2017.
  12. Shah, M.A., Jakkawanpitak, C., Sermwittayawong, D. and Panichayupakaranant, P.  Rhinacanthins-rich extract enhances glucose uptake and inhibits adipogenesis in 3T3‑L1 adipocytes and L6 myotubes.  Pharmacognosy Magazine , 13:  S817-S821, 2017.
  13. Septama, A.W. and Panichayupakaranant, P.  Antibacterial activity of artocarpanone isolated from Artocarpus heterophyllus heartwoods against diarrheal pathogens and its mechanism of action on membrane permeability.  Journal of Applied Pharmaceutical Science, 7:  64-68, 2017.
  14. Shah, M.A., Muhammad, H., Mehmood, Y., Khalil, R., Ul‑Haq, Z. and Panichayupakaranant, P.  Superoxide scavenging and antiglycation activity of rhinacanthins-rich extract obtained from the leaves of Rhinacanthus nasutus.  Pharmacognosy Magazine , 13:  652-658, 2017.
  15. Shah, M.A., Khalil, R., Ul-Haq, Z. and Panichayupakaranant, P.  α-Glucosidase inhibitory effect of rhinacanthins-rich extract from Rhinacanthus nasutus leaf and synergistic effect in combination with acarbose.  Journal of Functional Foods , 36:  325-331, 2017.
  16. Jaisi, A. and Panichayupakaranant, P.  Simultaneous heat shock and in situ adsorption enhance plumbagin production in Plumbago indica root cultures.  Engineering in Life Sciences , 16:  417-423, 2016.
  17. Panyo, J., Matsunami K. and Panichayupakaranant Bioassay-guided isolation and evaluation of antimicrobial compounds from Ixora megalophylla against some oral pathogens.  Pharmaceutical Biology , 54:  1522-1527, 2016.
  18. Septama, A.W. and Panichayupakaranant, P.  Simultaneous HPLC analysis of three flavonoids in the extracts of Artocarpus heterophyllus heartwoods.  Natural Product Sciences, 22:  77-81, 2016.
  19. Meerungrueang, W. and Panichayupakaranant, P.  A New Antibacterial Tetrahydronaphthalene Lignanamide, Foveolatamide, from the Stems of Ficus foveolata.  Natural Product Communications, 11:  91-94, 2016.
  20. Bundeesomchok, K., Filly, A., Rakotomanomana, N., Panichayupakaranant, P. and Chemat, F. Extraction of -mangostin from Garcinia mangostana L. using alternative solvents: Computational predictive and experimental studies.  LWT - Food Science and Technology, 65:  297-303, 2016.
  21. Adam, S.H., Giribabu, N., Rao, P.V., Md. Sayem, A.S., Arya, A., Panichayupakaranant, P., Korla, P.K., Salleh, N.  Rhinacanthin C ameliorates hyperglycaemia, hyperlipidemia and pancreatic destruction in streptozotocin–nicotinamide induced adult male diabetic rats.  European Journal of Pharmacology, 771:  173-190, 2016.
  22. Jaisi, A. and Panichayupakaranant, P. Increased production of plumbagin in Plumbago indica root cultures by biotic and abiotic elicitors.  Biotechnology Letters, 38:  351-355, 2016.
  23. Septama, A.W. and Panichayupakaranant, P. Synergistic effect of artocarpin on antibacterial activity of some antibiotics against methicillinresistant Staphylococcus aureus, Pseudomonas aeruginosa, and Escherichia coli.  Pharmaceutical Biology, 54:  686–691, 2016.
  24. Panichayupakaranant, P. and Ahmad, M.I.  Plumbagin and its role in chronic diseases.  Advances in Experimental Medicine and Biology, 992:  229-246 , 2016.
  25. Puttarak, P., Brantner, A and Panichayupakaranant, P.  Biological activities and stability of a standardized pentacyclic triterpene enriched Centella asiatica extract.  Natural Product Sciences, 22:  20-24, 2016.
  26. Meerungrueang, W. and Panichayupakaranant, P.  Quantitative HPLC analysis and extraction of 2,6-dimethoxy-1,4-benzoquinone from Ficus foveolata stems.  Natural Product Sciences, 21:  192-195, 2015.
  27. Mo, J., Kaewnopparat, N., Songkro, S., Panichayupakaranant, P. and Reanmongkol, W.  Physicochemical properties, in vitro release and skin permeation studies of a topical formulation of standardized pomegranate rind extract.  Pakistan Journal of Pharmaceutical Sciences , 28:  29-36, 2015.
  28. Puttarak, P., Pichayakorn, W., Sripoka, K., Chaimud, K. and Panichayupakaranant, P.  Preparation of Centella extracts loaded Aloe vera transdermal patches for wound healing purpose.  Advanced Materials Research , 1060:  54-57, 2015.
  29. Septama, A.W. and Panichayupakaranant, P. Antibacterial assay-guided isolation of antibacterial compounds from Artocarpus heterophyllus heartwoods.  Pharmaceutical Biology, 53:  1608 - 1613, 2015.
  30. Nirmal, N.P. and Panichayupakaranant, P.  Antioxidant, antibacterial, and anti-inflammatory activities of standardized brazilin-rich Caesalpinia sappan extract.  Pharmaceutical Biology, 53:  1339 – 1343, 2015.
  31. Nirmal, N.P., Benjakul, S., Ahmad, M., Arfat, Y.A., Panichayupakaranant, P.  Undesirable enzymatic browning in Crustaceans: Causative effects and its inhibition by phenolic compounds.  Critical Reviews in Food Science and Nutrition , 55:  1992-2003, 2015.
  32. Suedee, A., Tewtrakul, S. and Panichayupakaranant, P.  Anti-HIV-1 integrase activity of Mimusops elengi leaf extracts.  Pharmaceutical Biology, 52:  58-61, 2014.
  33. Simaratanamongkol, A., Umehara, K., Niki, H., Noguchi, H. and Panichayupakaranant, P. Angiotensin-converting enzyme (ACE) inhibitory activity ofSolanum torvumand isolation of a novel methyl salicylate glycoside.  Journal of Functional Foods , 11:  557-562, 2014.
  34. Mo, J., Panichayupakaranant, P., Kaewnopparat, N., Nitiruangjaras, A. and Reanmongkol, W. Wound healing activities of standardized pomegranate rind extract and its major antioxidant ellagic acid in rat dermal wounds.  Journal of Natural Medicines, 68:  377-386, 2014.
  35. Mo, J., Panichayupakaranant, P., Kaewnopparat, N., Songkro, S. and Reanmongkol, W. Topical anti-inflammatory potential of standardized pomegranate rind extract and ellagic acid in contact dermatitis.  Phytotherapy Research, 28:  629-632, 2014.
  36. Tokton, N., Ounaroon, A., Panichayupakaranant, P. and Tiyaboonchai, W.  Development of ellagic acid rich pomegranate peel extract loaded nanostructured lipid carriers (NLCS).  International Journal of Pharmacy and Pharmaceutical Sciences, 6:  259-265, 2014.
  37. Kaewbumrung, S. and Panichayupakaranant, P.  Antibacterial activity of plumbagin derivative-rich Plumbago indica root extracts and chemical stability.  Natural Product Research, 28:  835-837, 2014.
  38. Meerungrueang, W. and Panichayupakaranant, P.  Antimicrobial activities of some Thai traditional medical longevity formulations from plants and antibacterial compounds from Ficus foveolata..  Pharmaceutical Biology, 52:  1104 - 1109, 2014.
  39. Nirmal, N. and Panichayupakaranant, P.  Anti-Propionibacterium acnes assay guided purification of brazilin and preparation of brazilin rich extract from Caesalpinia sappan heartwood.  Pharmaceutical Biology, 52:  1204 – 1207, 2014.
  40. Simaratanamongkol, A., Umehara, K., Noguchi, H. and Panichayupakaranant, P. Identification of a new angiotensin-converting enzyme (ACE) inhibitor from Thai edible plants.  Food Chemistry, 165:  92–97, 2014.
  41. Bhusal, N., Panichayupakaranant, P. and Reanmongkol, W. In vivoanalgesic and anti-inflammatory activities of a standardized Rhinacanthus nasutusleaf extract in comparison with its major active constituent rhinacanthin-C.  Songklanakarin Journal of Science Technology, 36 :  325-331, 2014.
  42. Sakunphueak, A., Tansakul, P., Umehara, K., Noguchi, H. and Panichayupakaranant, P. Effect of methionine on production of naphthoquinones in Impatiens balsamina root cultures and detection of some secondary metabolites.  Pharmaceutical Biology, 51:  36-41, 2013.
  43. Suedee, A., Tewtrakul, S. and Panichayupakaranant, P.  Anti-HIV-1 integrase compound from Pometia pinnata leaves.  Pharmaceutical Biology, 51:  1256-1261, 2013.
  44. Sakunpak, A., Matsunami, K., Otsuka, H., Panichayupakaranant, P. Isolation of new monoterpene coumarins from Micromelum minutum leaves and their cytotoxic activity against Leishmania major and cancer cells .  Food Chemistry, 139:  458-463, 2013.
  45. Puttarak, P. and Panichayupakaranant, P. A new method for preparing pentacyclic triterpene rich Centella asiatica extracts.  Natural Product Research, 27:  684 - 686, 2013.
  46. Mo, J., Panichayupakaranant, P., Kaewnopparat , N., Nitiruangjaras, A. and Reanmongkol, W.  Topical anti-inflammatory and analgesic activities of standardized pomegranate rind extract in comparison with its marker compound ellagic acid in vivo.  Journal of Ethnopharmacology, 148:  901-908, 2013.
  47. Jaisi, A., Sakunphueak, A. and Panichayupakaranant, P.  Increased production of plumbagin in Plumbago indica root cultures by gamma ray irradiation.  Pharmaceutical Biology, 51:  1047 - 1051, 2013.
  48. Nittayananta, W., Pangsomboon, K., Panichayupakaranant, P., Chanowanna, N. , Chelae, S., Vuddhakul, V., Sukhumungoon, P. and Pruphetkaew, N. Effects of lawsone methyl ether mouthwash on oralCandida in HIV-infected subjects and subjects with denture stomatitis.  Journal of Oral Pathology and Medicine , 42:  698-704, 2013.
  49. Puttarak, P. and Panichayupakaranant, P.  Factors affecting the content of pentacyclic triterpenes in Centella asiatica raw materials .  Pharmaceutical Biology, 50:  1508-1512, 2012.
  50. Kaewchoothong, A., Tewtrakul, S. and Panichayupakaranant, P. Inhibitory effect of phenylbutanoid-rich Zingiber cassumunar extracts on nitric oxide production by murine macrophage-like RAW264.7 cells.  Phytotherapy Research, 26:  1789-1792, 2012.
  51. Kaewbumrunga, S. and Panichayupakaranant, P. Isolation of three antibacterial naphthoquinones from Plumbago indica roots and development of a validated quantitative HPLC analytical method.  Natural Product Research, 26:  2020-2023, 2012.
  52. Sakunphueak, A. and Panichayupakaranant, P. Comparison of antimicrobial activities of naphthoquinones from Impatiens balsamina.  Natural Product Research, 26:  1119-1124, 2012.
  53. Sakunpak, A. and Panichayupakaranant, P. Antibacterial activity of Thai edible plants against gastrointestinal pathogenic bacteria and isolation of a new broad spectrum antibacterial polyisoprenylated benzophenone, chamuangone .  Food Chemistry, 130:  826-831, 2012.
  54. Seetrairat, N., Nukul, N., Intasem, P., Sansuk, A., Prasirt, J., Leewatthanakorn, T., Piamsawad, U., Dejrudee, A., Panichayupakaranant, P., Pangsomboon, K., Chanowanna, N., Hintao, J., Teanpaisan, R. et al. Antifungal activity of lawsone methyl ether in comparison with chlorhexidine.  Journal of Oral Pathology and Medicine, 40:  90-96, 2011.
  55. Panichayupakaranant, P., Issuriya, A., Sirikatitham,A. and Wang, W. Antioxidant assay-guided purification and liquid chromatographic determination of ellagic acid in pomegranate peel.  Journal of Chromatographic Science, 48:  456-459, 2010.
  56. Puttarak, P., Charoonratana, T. and Panichayupakaranant, P. Antimicrobial activity and stability of rhinacanthins-rich Rhinacanthus nasutus extract.  Phytomedicine, 17:  323-327, 2010.
  57. Panichayupakaranant, P., Issuriya, A. and Sirikatitham, A.  Preparation method and stability of ellagic acid rich pomegranate fruit peel extract.  Pharmaceutical Biology , 48:  201-205, 2010.
  58. Hutadilok-Towatana, N., Reanmongkol, W. and Panichayupakaranant, P. Evaluation of the toxicity of Arthrospira (Spirulina) platensis extract.  Journal of Applied Phycology, 22:  599-605, 2010.
  59. Niyomkam, P., Kaewbumrung, S., Kaewnpparat, S. and Panichayupakaranant, P.  Antibacterial activity of Thai herbal extracts on acne involved microorganism.  Pharmaceutical Biology, 48:  375-380, 2010.
  60. Sakunphueak, A. and Panichayupakaranant, P. Effects of donor plants and plant growth regulators on naphthoquinone production in root cultures of Impatiens balsamina .  Plant Cell Tissue and Organ Culture, 102:  9-15, 2010.
  61. Panichayupakaranant, P. and Meerungrueang, W. Effect of medium composition and light on root and rhinacanthin formation in Rhinacanthus nasutus cultures.  Pharmaceutical Biology, 48:  1192-1197, 2010.
  62. Sakunphueak, A. and Panichayupakaranant, P.  Simultaneous determination of three naphthoquinones in the leaves of Impatiens balsamina L. by reversed-phase high-performance liquid chromatography.  Phytochemical Analysis, 21:  444-450, 2010.
  63. Panichayupakaranant, P., Tewtrakul S. and Yuenyongsawad, S.  Antibacterial, anti-inflammatory and anti-allergic activities of standardised pomegranate rind extract.  Food Chemistry, 123:  400-403, 2010.
  64. Sakunphueak, A. and Panichayupakaranant, P.  Increased production of naphthoquinones in Impatiens balsamina root cultures by elicitation with methyl jasmonate.  Bioresource technology, 101:  8777-8783, 2010.
  65. Mahattanadul, S., Nakamura, T., Panichayupakaranant, P., Phdoongsombut, N., Tungsinmunkong, K. and Bouking, P.  Comparative antiulcer effect of bisdemethoxycurcumin and curcumin in a gastric ulcer model system .  Phytomedicine, 16:  342-351, 2009.
  66. Panichayupakaranant, P., Charoonratana, T. and Sirikatitham, A.  RP-HPLC analysis of rhinacanthins in Rhinacanthus nasutus: validation and application to preparation of rhinacanthin high-yielding extract.  Journal of Chromatographic Science, 47:  705-708, 2009.
  67. Sakunpak, A., Sirikatitham, A. and Panichayupakaranant, P. Preparation of anthraquinone high-yielding Senna alata extract and its stability.  Pharmaceutical Biology, 47:  236-241, 2009.
  68. Panichayupakaranant, P., Sakunpak, A. and Sakunpheuak, A. Quantitative HPLC determination and extraction of anthraquinones in Senna alata leaves.  Journal of Chromatographic Science, 47:  197-200, 2009.
  69. Tewtrakul, S., Tansakul, P. and Panichayupakaranant, P. Effects of rhinacanthins from Rhinacanthus nasutus on nitricoxide, prostaglandin E2 and tumor necrosis factor-alpha releases using RAW264.7 macrophage cells.  Phytomedicine, 16:  581–585, 2009.
  70. Tewtrakul, S., Tansakul, P. and Panichayupakaranant, P. Anti-allergic principles of Rhinacanthus nasutus leaves.  Phytomedicine, 16:  929-934, 2009.
  71. Waranyoupalin, R., Wongnawa, S., Wongnawa, M., Pakawatchai, C., Panichayupakaranant, P. and Sherdshoopongse, P.  Studies on complex formation between curcumin and Hg(II) ion by spectrophotometric method: A new approach to overcome peak overlap.  Central European Journal of Chemistry , 7:  388-394, 2009.
  72. Hutadilok-Towatana, N., Reanmongkol, W., Satitit, S., Panichayupakaranant, P. and Ritthisunthorn, P.  A subchronic toxicity study of Spirulina platensis.  Food Science and Technology Research, 14:  351-358, 2008.
  73. Panichayupakaranant, P., Chatkrapunt, U. and Supavita, T. Pharmacognostic and chemical studies on the leaves of Rhinacanthus nasutus.  Nigerian Journal of Natural Products and Medicine, 10:  1-5, 2006.
  74. Mahattanadul, S., Reanmongkol, W., Yano, S. and Panichayupakaranant, P., Phadoongsombut, N. and Tungsinmunkong, K. Preventive and curative effects of curcumin on the development of gastric inflammatory diseases in rats.  Journal of Natural Medicines, 60:  191-197, 2006.
  75. Mahattanadul, S., Nisaudah Radenahmad, N., Phadoongsombut, N., Thitima Chuchom, T., Panichayupakaranant, P., Yano, S. and Reanmongkol, W. Effects of curcumin on reflux esophagitis in rats .  Journal of Natural Medicines, 60:  198-205, 2006.
  76. Chatsiriwej, N., Wungsintaweekul, J. and Panichayupakaranant, P.  Anthraquinone production in Senna alata root cultures.  Pharmaceutical Biology, 6:  416-420, 2006.
  77. Qian, B., Panichayupakaranant, P., Sirikatitham, A., Zhang R.P., Guo, Y.D. and Wu, Y.Q. Quantitative HPLC determination of indigotin and indirubin in indigo naturalis.  Ars Pharmaceutica, 46(4):  399-408, 2005.
  78. Kovitwanawong, N., Preechavai, C., Panichayupakaranant, P. and Watanayomnaporn E. Ginger for prevention of postoperative nausea and vomiting in outpatiens undergoing gynecologic laparoscopic procedure at Songklanagarind Hospital.  Thai Journal of Anesthesiology, 30 (4):  146-152, 2004.
  79. Panichayupakaranant, P. and Kaewsuwan, S. Bioassay-guided isolation of the antioxidant constituent from Cassia alata L. leaves.  Songklanakarin J. Sci. Technol., 26(1):  103-107, 2004.
  80. Panichayupakaranant, P. and Intaraksa, N. Distribution of hydroxyanthracene derivatives in Cassia alata and the factors affecting the quality of the raw material.  Songklanakarin J. Sci. Technol., 25 (4):  497-502, 2003.
  81. Panichayupakaranant, P. and Reanmongkol, W. Evaluation of chemical stability and skin irritation of lawsone methyl ether in oral base.  Pharmaceutical Biology, 40 (6):  429-432, 2002.
  82. Panichayupakaranant, P. and Tewtrakul, S. Plumbagin production by root cultures of Plumbago rosea.  Electronic Journal of Biotechnology , 5:  228-232, 2002.
  83. Panichayupakaranant, P.  ìNaphthoquinones formation in Impatiens balsamina cell cultures.  Pharmaceutical Biology, 39 (4):  293-296, 2001.
  84. Panichayupakaranant, P., Yuenyongsawad, S. and Reanmongkol, W Lawsone methyl ether in oral base and its chemical stability.  Songklanakarin J. Sci. Technol., 22(4):  523-527, 2000.
  85. Panichayupakaranant, P. Rattanasuwan, P. and Kadae, P.  Preparation of bulk laxative capsule from mucilage of Ocimum canum.  Songklanakarin J. Sci. Technol., 21(4):  441 - 446, 1999.
  86. Panichayupakaranant, P. Study on methyl source in scopoletin and isofraxidin biosynthesis .  Songklanakarin J. Sci. Technol., 21(4):  435 - 439, 1999.
  87. Panichayupakaranant, P., Noguchi, N. and De-Eknamkul, W. A new biscoumarin from Impatiens balsamina root cultures.  Planta Medica, 64:  774-775, 1998.
  88. Panichayupakaranant, P and Sinsawaiphon, S Coumarin derivative formation in Impatiens balsamina cell culture.  Songklanakarin J. Sci. Technol., 20(4):  485 - 488, 1998.
  89. Panichayupakaranant, P. Noguchi, H. De-Eknamkul, W. and Sankawa, U.  Naphthoquinone and coumarin from root cultures of Impatiens balsamina.  Phytochemistry, 40:  1141 - 1143, 1995.
  90. Panichayupakaranant, P. and De-Eknamkul, W.  Study on naphthoquinone formation in in vitro cultures of Impatiens balsamina L..  Thai J. Pharm. Sci., 16:  29 - 37, 1992.
  91. Panichayupakaranant, P. and De-Eknamkul, W. Enzymatic methylation of lawsone to 2-methoxy-1,4-naphthoquinone in Impatiens balsamina leaves.  Thai J. Pharm. Sci., 16:  287 - 289, 1992.