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Education ::
  - Bachelor of Science in Pharmacy , Pharmacy, Prince of Songkla University, 1992
  - Master of Science in Pharmacy, Pharmacognosy, Chulalongkorn University, 1995
  - Doktor der Naturwissenschaften, Biochemistry, Technical University of Munich, 2001

Main Fields of Scientific Interests ::
  - ËÑÇ¢éÍÇԨѷÕèʹ㨠¤×Í ¡ÒÃÈÖ¡ÉÒªÕÇÊѧà¤ÃÒÐËì¢Í§ÊÒ÷صÔÂÀÙÁÔ㹾ת àªè¹ à·ÍÃì»Õ¹ áÍŤÒÅÍ´ì à»ç¹µé¹ ÍÒÈÑÂà·¤¹Ô¤·Ò§à¤ÁÕ ªÕÇà¤ÁÕ áÅÐͳ٪ÕÇÇÔ·ÂÒ ¹Í¡¨Ò¡¹ÕéÂѧʹ㨧ҹÇԨѷÕèãªéªÕÇà¤ÁÕà»ç¹°Ò¹ ¤×Í ¡ÒÃÈÖ¡ÉÒ¡Åä¡¡ÒÃÍÍ¡Ä·¸Ôì¢Í§ÊÒèҡ¸ÃÃÁªÒµÔ àªè¹ ¡Åä¡·Õèà¡ÕèÂÇ¢éͧ¡Ñºâ»Ãá¡ÃÁ¡ÒõÒ¢ͧà«ÅÅì ÊÓËÃѺÊÒõéÒ¹ÁÐàÃç§ ¡Åä¡¡ÒÃÂѺÂÑ駡ÒÃÊÃéÒ§ÊÒÃÍÑ¡àʺ à»ç¹µé¹ ¹Í¡¨Ò¡¹ÕéÂѧÁÕ¡ÒÃÊÃéÒ§ÊÒÃÀÙÁÔµéÒ¹·Ò¹µèÍÊÒ÷Õèá¡ä´é¨Ò¡¸ÃÃÁªÒµÔ à¾×è;Ѳ¹Òä»à»ç¹à¤Ã×èͧÁ×͵ÃǨÊͺ¤Ø³ÀÒ¾¢Í§ÊÁعä¾Ã ÍÕ¡´éÇÂ
Our research interest is based on pharmaceutical biotechnology, especially in natural products. Our research topics are biosynthetic study of secondary metablites, molecular biology, plant tissue culture, purification and characterization of proteins and production of monoclonal antibody. All facilities served for post-doctoral, Ph.D students, master students and undergraduate students. Our grants support are provided such as Prince of Songkla University, National Research Council of Thailand, the Thailand Research Fund, the Commission of Higher Education.


Fields of specialist ::
  - Biosynthesis of plant secondary metabolites; plant tissue culture; plant molecular biology; expression and purification of protein; monoclonal antibody production


Research ::

  Publication ::
  1. Premprasert, C., Tewtrakul, S., Plubrukarn, A and Wungsintaweekul, J. Anti-inflammatory activity of diterpenes from Croton stellatopilosus on LPS-induced RAW264.7 cells.  Journal of Natural Medicines, 67:  174-181, 2013.
  2. Kongduang, D., Wungsintaweekul, J. and De-Eknamkul, W. Established GC-FID for simultaneous determination of diterpenes and phytosterols in Plaunoi (Croton stellatopilosus Ohba).  Songklanagarind Journal of Science and Technology, 34(6):  623-628, 2012.
  3. Wungsintaweekul, J, Choo-malee, Charoonratana, C. and Keawpradub, N. Methyl jasmonate and yeast extract stimulate mitragynine production of Mitragyna speciosa (Roxb.)Korth. shoot culture.  Biotechnology Letters, 34(10):  1945-1950, 2012.
  4. Songkro, S., Pichayakorn, W., Sungkarak, S. and Wungsintaweekul, J.  Investigation of Plaunoi-loaded micro/nanoemulsions for the treatment of dermatitis: formulation, evaluation and skin irritation studies.  J. Drug.Del.Sci.Tech. , 21(5):  401-410, 2011.
  5. Wungsintaweekul, J., Sitthithaworn, W., Putalun, W. Pfeifhoffer, H.W. and Brantner, A. Antimicrobial, antioxidant activities and chemical composition of selected Thai spices. .  Songklanakarin J. Sci. Technol., 32(6):  589-598, 2010.
  6. Sitthithaworn, W., Wungsintaweekul, J., Sitisuntipong, T., Charoonratana, T., Ebizuka, Y. and De-Eknamkul, W. Cloning of 1-deoxy-D-xylulose 5-phosphate synthase from Croton stellatopilosus and expression with 2C-methyl-D-erythritol 4-phosphate synthase and geranylgeranyl diphosphate synthase, key enzymes in plaunotol biosynthesis. .  J. Plant Physiol., 167(4):  292-300, 2010.
  7. Songkro, S., Sirikatitham, A., Sungkarak, S., Buaking, K., Wungsintaweekul,J., Maneewan, D. and Oungbho, K.  Characterization of Aromatherapy massage oils prepared from virgin coconut oil and some essential oils..  J. Am. Oil Chem. Soc. , 87(1):  93-107, 2010.
  8. Treetharnmathurot, B., Ovartlarnporn, C., Wungsintaweekul, J., Duncan R. and Wiwattanapatapee, R.  Effect of PEG molecular weight and linking chemistry on the biological activity and thermal stability of PEGylated trypsin. .  Int. J. Pharmaceutics, 357:  252-259, 2008.
  9. Wungsintaweekul, J., Sirisuntipong, T., Kongduang, D., Losuphanporn, T., Ounaroon, A., Tansakul, P. and De-Eknamkul, W.  Transcription profiles of genes encoding 1-deoxy-D-xylulose 5-phosphate synthase and 2C-methyl-D-erythritol 4-phosphate synthase in plaunotol biosynthesis from Croton stellatopilosus. .  Biol. Pharm. Bull. , 31(5):  852-856, 2008.
  10. Kongduang, D., Wungsintaweekul, J. and De-Eknamkul, W.  Biosynthesis of -sitosterol and stigmasterol proceeds exclusively via the mevalonate pathway in cell suspension cultures of Croton stellatopilosus.  Tetrahedron Lett. , 49:  4067-4072, 2008.
  11. Songkro, S., Wungsintaweekul, J. and Chartwaingam, S.  Investigation of enhancing activity and skin irritation of Zingiber officinale, Zingiber cassumunar and Curcuma zedoaria.  J. Drug Del. Sci. Tech, 18(3):  169-179, 2008.
  12. Phongprueksapattana, S., Putalun, W., Keawpradub, N., Wungsintaweekul, J Mitragyna speciosa: Hairy Root Culture for Triterpenoid Production and High Yield of Mitragynine by Regenerated Plants.  Z. Naturforsch., 63C:  691-698 , 2008.
  13. Wungsintaweekul, J., Sriyapai, C., Kaewkerd, S., Tewtrakul, S., Kongduang, D. and De-Eknamkul, W.  Establishment of Croton stellatopilosus suspension culture for geranylgeraniol production and diterpenoid biosynthesis. .  Z. Naturforsch. , 62C:  389-396, 2007.
  14. Chatsiriwej, N., Wungsintaweekul, J. and Panichayupakaranant, P.  Anthraquinone production in Senna alata root cultures..  Pharm. Biol., 44:  416-420, 2006.
  15. Wungsintaweekul , J. and De-Eknamkul, W.  Biosynthesis of plaunotol in Croton stellatopilosus proceeds via the deoxyxylulose phosphate pathway.  Tetrahedron Lett. , 46(12):  2125-2128, 2005.
  16. Steinbacher S, Kaiser J, Wungsintaweekul J, Hecht S, Eisenreich W, Gerhardt S, Bacher A, Rohdich F. Structure of 2C-methyl-d-erythritol-2,4-cyclodiphosphate synthase involved in mevalonate-independent biosynthesis of isoprenoids..  Journal of Molecular Biology , 316(1):  79-88, 2002.
  17. Fellermeier, M., Raschke, M., Sagner, S., Wungsintaweekul, J., Schuhr, C.A., Hecht, S., Radykewicz, T., Adam, P., Rohdich, F., Eisenreich, W., Bacher, A., Arigoni, D. and Zenk, M.H. Studies on the nonmevalonate pathway of terpene biosynthesis The role of 2C-methyl-D-erythritol 2,4-cyclodiphosphate in plants.  European Journal of Biochemistry, 268:  6302-6310, 2001.
  18. Hecht, S., Wungsintaweekul, J., Rohdich, F., Kis, K., Radykewicz, T., Schuhr, C.A., Eisenreich, W., Richter, G. and Bacher, A. Biosynthesis of terpenoids: Efficient multistep biotransformation procedure affording isotope-labeled 2C-methyl-D-erytritol 4-phosphate using recombinant 2C-methyl-D-erythritol 4-phosphate synthase.  J. Org. Chem., 66:  7770-7775, 2001.
  19. Schuhr, C., Hecht, S., Kis, K., Eisenreich, W., Wungsintaweekul, J., Bacher, A. and Rohdich, F. Studies on the non-mevalonate pathway- Preparation and properties of isotope-labeled 2C-methyl-D-erythritol 2,4-cyclodiphosphate.  Eur. J. Org. Chem., -:  3221-3226, 2001.
  20. Hecht S, Kis K, Eisenreich W, Amslinger S, Wungsintaweekul J, Herz S, Rohdich F, Bacher A. Enzyme-assisted preparation of isotope-labeled 1-deoxy-d-xylulose 5-phosphate..  J. Org. Chem., 66(11):  3948-3952, 2001.
  21. Rohdich, F., Eisenreich, W., Wungsintaweekul, J., Hecht, S., Schuhr, C.A. and Bacher, A. Biosynthesis of terpenoids: 2C-Methyl-D-erythritol 2,4-cyclodiphosphate synthase (IspF) from Plasmodium falciparum.  Eur. J. Biochem., 268:  3190-3197, 2001.
  22. Wungsintaweekul, J., Herz, S., Hecht, S., Eisenreich, W., Feicht, R., Rohdich, F., Bacher, A and Zenk, M.H. Phosphorylation of 1-deoxy-D-xylulose by D-xylulokinase of Escherichia coli.  Eur. J. Biochem., 267:  310-316, 2001.
  23. Kis, K., Wungsintaweekul, J., Eisenreich, W., Zenk, M.H. and Bacher, A. An efficient preparation of 2-C-methyl-D-erythritol 4-phosphoric acid and its derivatives.  J.org.Chem., 65:  587-592, 2000.
  24. Radykewicz, T., Rohdich, F., Wungsintaweekul, J., Herz, S., Kis, K., Eisenreich, W., Bacher, A., Zenk, M.H. and Arigoni, D.  Biosynthesis of terpenoids: 1-deoxy-D-xylulose 5-phosphate reductoisomerase from Escherichia coli is a class B dehydrogenase.  FEBS Letters, 465:  157-160, 2000.
  25. Lüttgen, H., Rohdich, F., Herz, S., Wungsintaweekul, J., Hecht, S., Schuhr, C.A., Fellermeier, M., Sagner, S., Zenk, M.H., Bacher, A. and Eisenreich, W. Biosynthesis of terpenoids: YchB protein of Escherichia coli phosphorylates the 2-hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol.  Proc. Natl. Acad. Sci. USA, 97:  1062-1067, 2000.
  26. Herz, S., Wungsintaweekul, J., Schuhr, C.A., Hecht, S., Lüttgen, H., Sagner, S., Fellermeier, M., Eisenreich, W., Zenk, M.H., Bacher, A. and Rohdich, F. Biosynthesis of terpenoids: YgbB protein converts 4-diphosphocytidyl-2C-methyl-D-erythritol 2-phosphate to 2C-methyl-D-erythritol 2,4-cyclodiphosphate.  Proc. Natl. Acad. Sci. USA, 97:  2486-2490, 2000.
  27. Rohdich, F., Wungsintaweekul, J., Eisenreich, W., Richter, G., Schuhr, C.A., Hecht, S., Zenk, M.H. and Bacher, A. Biosynthesis of terpenoids: 4-diphosphocytidyl-2C-methyl-D-erythritol synthase of Arabidopsis thaliana.  Proc. Natl. Acad. Sci. USA, 97:  6451-6456, 2000.
  28. Rohdich, F.. Wungsintaweekul, J., Lÿttgen, H., Fischer, M., Eisenreich, W., Schuhr, C.A., Fellermeier, M., Schramek, N., Zenk, M.H. and Bacher, A. Biosynthesis of terpenoids: 4-diphosphocytidyl-2C-methyl-D-erythritol kinase from tomato.  Proc. Natl. Acad. Sci. USA, 97:  8251-8256, 2000.
  29. Rohdich, F., Schuhr, C.A., Hecht, S., Herz, S., Wungsintaweekul, J., Eisenreich, W., Zenk. M.H. and Bacher, A. Biosynthesis of isoprenoids. A rapid method for the preparation of isotope-labeled 4-diphosphocytidyl-2C-methyl-D-erythritol.  J. Am. Chem. Soc, 122:  9571-9574, 2000.
  30. Rohdich, F., Wungsintaweekul, J., Fellermeier, M., Sagner, S., Herz, S., Kis, K., Eisenreich,W. Bacher, A. and Zenk, M.H. Cytidine 5‘-triphosphate-dependent biosynthesis of isoprenoid: YgbP protein of Escherichia coli catalyzes the formation of 4-diphosphocytidyl-2-C-methylerythritol.  Proc. Natl. Acad. Sci. USA, 96:  11758-11763, 1999.
  31. Arigoni, A., Giner, J-L., Sagner, S., Wungsintaweekul, J., Zenk, M.H., Kis, K., Bacher, A. and Eisenreich, W.  Stereochemical course of the reduction step in the formation of 2C-methylerythritol from the terpene precursor 1-deoxyxylulose in higher plants.  Chem. Commun., -:  1127-1128, 1999.