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  18 กุมภาพันธ์ 2563

อดิศร รัตนพันธ์

หมายเลขโทรศัพท์ ::  66-7428-8867
อีเมล์ ::  adisorn.r@psu.ac.th
โฮมเพจส่วนตัว ::  -



 
ประวัติการศึกษา ::
  - วิทยาศาสตรบัณฑิต, เคมี, ม.สงขลานครินทร์, 2524
  - วิทยาศาสตรมหาบัณฑิต, ชีวเคมี, ม.มหิดล, 2527
  - Doktor der Naturwissenschaften, Biochemistry & Biotechnology , Universitaet Regensburg, 2537

งานวิจัยที่สนใจ ::
  - Cancer Research;
Anticancer Platinum/Ruthenium Drugs; Breast Cancer Suppressor Gene 1 (BRCA1)and its encoded product;
Steroid Hormone Regulation of Gene Expression


สาขาที่เชี่ยวชาญ ::
  - Cancer Biology and Therapy;
Human Molecular Genetics


ผลงานวิชาการ ::

  บทความวิจัยตีพิมพ์ในวารสารวิชาการ ::
  1. Atipairin, A., Canyuk, B. and Ratanaphan, A.  Cisplatin affects the conformation of apo-form, not holo-form, of BRCA1 RING finger domain and confers thermal stability.  Chemistry & Biodiversity, (doi: 10.1002/cbdv.200900308):  (doi: 10.1002/cbdv.200900308), 2010.
  2. Ratanaphan, A., Temboot, P. and Dyson, P.J.  In vitro ruthenation of human breast cancer suppressor gene 1 (BRCA1) by the antimetastasis compound RAPTA-C and its analogue carboRAPTA-C.  Chemistry & Biodiversity, 7:  1290-1302, 2010.
  3. Ratanaphan, A., Wasiksiri, S., Canyuk, B. and Prasertsan, P.  Cisplatin-damaged BRCA1 exhibits altered thermostability and transcriptional transactivation.  Cancer Biology & Therapy, 8 :  890-898 , 2009.
  4. Ratanaphan, A., Wasiksiri, S., Canyuk, B. and Mahasawat, P.  In vitro platination of human breast cancer suppressor gene 1 (BRCA1) by the anticancer drug carboplatin.  Biochimica et Biophysica Acta, General Subjects, 1725:  145-151, 2005.
  5. Jitpukdeebodintra, S., Chantachum, S., Ratanaphan, A. and Chantrapromma, K. Preliminary study on immunomodulatory property of limonin from lime seeds.  Journal of Food, Agriculture & Environment, 3:  109-111, 2005.
  6. Jitpukdeebodintra, S., Chantachum, S., Ratanaphan, A. and Chantrapromma, K. Stability of limonin from lime seeds .  Journal of Food, Agriculture & Environment , 3:  99-100, 2005.
  7. Gross, E, Seck, K., Neubauer, S., Mayr, J., Hellebrand, H., Ratanaphan, A., Lutz, V., Stockinger, H. and Kiechle, M. High-throughput genotyping by DHPLC of the dihydro-pyrimidine dehydrogenase gene implicated in (fluoro) pyrimidine catabolism. .  Int. J. Oncol. , 22:  325-332., 2003.
  8. Ratanaphan, A., Nukaga, M. and Sawai, T.  Mutation of class C ิิำbeta-lactamase..  Songklanakarin Journal of Science and Technology., vol. 21, no. 1,:  83-88., 1999.
  9. Ratanaphan, A. and Kraikitayakul, P. Analysis of Paracetamol, Salicylamide, and Caffeine in Commercial Analgesic Dosage Forms by High Performance Liquid Chromatography.  Songklanakarin Journal of Science and Technology, vol. 10, no. 4 :  397-403, 1988.
  10. Ratanaphan, A. and Ruenwongsa, P. Alteration in properties of Thymidylate Synthetase from Pyrimethamine-resistant Plasmodium chabaudi.  Int. J. Parasitol., 16:  483-490, 1986.
  11. Pattanakitsakul, S., Ratanaphan, A. and Ruenwongsa, P. Comparative Studies on Thymidylate Synthetase from Plasmodium berghei and mouse reticulocytes.  Comp. Biochem. Physiol., 80B:  583-587, 1985.
  บทความวิจัยเสนอในที่ประชุมวิชาการและมีการพิมพ์รวมเล่ม ::
  1. Ratanaphan, A.. A Potential Drug Target for the Anticancer Platinum Drug Cisplatin.  BIT’s 3rd Annual World Cancer Congress: Breast Cancer Conference 2010 – Fighting Breast Cancer at Molecular Level.  -, Shanghai, China,  25-27 4, 2010
  2. Temboot, P., Ratanaphan, A. and Dyson, P.J. . Human Breast Cancer Susceptibility Gene 1 (BRCA1) Damaged by Ruthenium(II)-Arene PTA (RAPTA) Complexes.  RGJ-Ph.D. Congress X.  -, Chonburi, Thailand,  3-5 4, 2009
  3. Atipairin, A., Canyuk, B. and Ratanaphan, A. . Substitution of aspartic acid with glutamic acid at position 67 of BRCA1 RING domain exhibits thermal instability.  The 2nd Biochemistry and Molecular Biology for Regional Sustainable Development.  -, Khon Kaen, Thailand,  7-8  5, 2009
  4. Ratanaphan, A., Temboot, P., and Dyson, P.J. . In vitro ruthenation of human breast cancer susceptibility gene 1 (BRCA1) by the anticancer RAPTA complexes.  21st IUBMB and 12th FAOBMB International Congress of Biochemistry and Molecular Biology.  -, Shanghai, China,  2-7  8, 2009
  5. Chakree, K., Ovatlarnporn, C, Dyson, P.J. and Ratanaphan, A. . In vitro ruthenation of human breast cancer susceptibility gene BRCA1 by the ruthenium(II)-arene complex (RAPTA-EA1).  The 35th Congress on Science and Technology of Thailand (STT 35).  -, Chonburi, Thailand,  15-17 10, 2009
  6. Ratanaphan, A., Wasiksiri, S. and Canyuk, B. and Prasertsan, P. . Direct interaction of BRCA1 with the anticancer drug cisplatin: repair-mediated transcriptional activation of BRCT.  19th FAOBMB Seoul Conference.  -, Seoul, South Korea,  27-30 5, 2007
  7. Ratanaphan, A., Wasiksiri, S. and Canyuk, B. . Altered thermal stability of human BRCA1 gene induced by magnesium chloride and the anticancer platinum drug cisplatin.  20th IUBMB International Congress of Biochemistry and Molecular Biology and 11th FAOBMB Congress.  -, Kyoto, Japan,  18-23 6, 2006
  8. Ratanaphan, A., Wasiksiri, S. and Canyuk, B. . Effects of the anticancer drug cisplatin on human BRCA1 gene: cellular DNA repair and transcriptional transactivation activity.  11th International Congress of Human Genetics.  -, Brisbane, Australia,  6-10 8, 2006
  9. Ratanaphan, A., Supaprutsakul, S., Papol, T. and Canyuk, B. . A semi-automated DHPLC method for rapid screening of known BRCA1 mutations identified in Thai breast cancer patients, Mutation Detection.  VIII International Symposium on Mutations in the Genome.  -, Santorini, Greece,  31-4 5-6, 2005
  10. Ratanaphan, A., Wasiksiri, S. and Canyuk, B. . Damage and repair of the breast cancer susceptibility gene 1 (BRCA1) induced by the anticancer drug cisplatin.  The 5th Princess Chulabhorn International Science Congress: Evolving Genetics and Its Global Impact.  -, Bangkok, Thailand,  16-20  8, 2004
  11. Supaprutsakul, S., Papol, T., Canyuk, B. and Ratanaphan, A. . Analysis of known mutant BRCA1 gene identified in Thai breast/ovarian cancer patients by denaturing high-performance liquid chromatography (DHPLC).  The 5th Princess Chulabhorn International Science Congress: Evolving Genetics and Its Global Impact.  -, Bangkok, Thailand,  16-20  8, 2004
  12. Panomwan, P., Samphao, S., Hiranyakas, N., Canyuk, B., Maipang, T. and Ratanaphan, A. . Mutation screening of the breast cancer susceptibility gene 1 (BRCA1) in Thai breast cancer patients.  The 5th Princess Chulabhorn International Science Congress: Evolving Genetics and Its Global Impact.  -, Bangkok, Thailand,  16-20 8, 2004
  13. Atipairin, A., Canyuk, B. and Ratanaphan, A. . Molecular cloning and expression of the D67E mutant breast cancer susceptibility gene 1 (BRCA1) protein.  The 5th Princess Chulabhorn International Science Congress: Evolving Genetics and Its Global Impact.  -, Bangkok, Thailand,  16-20 8, 2004
  14. Ratanaphan, A., Wasiksiri, S. and Canyuk, B. . Analysis of cisplatin incorporation into human breast adenocarcinoma MCF-7 cells by quantitative polymerase chain reaction.  World Congress of Pharmacy and Pharmaceutical Sciences 2004, 64th Congress of FIP.  -, New Orleans, USA,  4-9 9, 2004
  15. Ratanaphan, A., Canyuk, B., Wasiksiri, S., Atipairin, A., and Mahasawat, P. . Human Breast Cancer Suppressor Gene1 (BRCA1): Analysis of DNA Damage and Gene Expression.  The 3rd Indochina Conference on Pharmaceutical Sciences (Pharma Indochina III), Pharmacy for Better Quality of Life.  -, Bangkok, Thailand,  21-23 5, 2003
  16. Ratanaphan, A., Canyuk, B., Mahasawat, P., and Wasiksiri, S. . Analysis of the breast cancer suppressor gene (BRCA1) damaged by cisplatin using gel electrophoresis, restriction digestion and quantitative polymerase chain reaction.  XIX International Congress of Genetics, Genomes–The Linkage to Life.  -, Melbourne, Australia,  6-12 7, 2003
  17. Ratanaphan, A., Canyuk, B., Atipairin, A., and Wasiksiri, S. . Molecular cloning and expression of the C-terminal region of human BRCA1 (BRCT) protein induced by the bacterial pho A promoter.  XIX International Congress of Genetics, Genomes–The Linkage to Life.  -, Melbourne, Australia,  6-12 7, 2003
  18. Ratanaphan, A., Wasiksiri, S. and Canyuk, B.. Thermal stability of human breast cancer suppressor gene (BRCA1).  10th Congress of Federation of Asian & Oceanian Biochemists and Molecular Biologists.  -, Bangalore, India,  7-11  12, 2003
  19. Wasiksiri, S., Sriroongrueng, W., Canyuk, B., Prasertsan, P. and Ratanaphan, A. . Thermal Characterization of the Breast Cancer Susceptibility Gene1 (BRCA1).  The 14th Annual Meeting of the Thai Society for Biotechnology, Biotechnology for Better Living in the New Economy.  -, Hotel Sofitel Raja Orchid, Khon Kaen,  12-15  11, 2002
  20. Rudeeaneksin, J., Presertsan, P. and Ratanaphan, A.. In Vitro Inhibitory Effects of Antitumor Platinum Complexes on DNA Synthesis.  The third regional IMT-GT Uninet Conference (IMT-GT 2000), Land Development and Sustainable Bioresources.  103, Medan, Indonesia,  10-12 October, 2000
  21. Ratanaphan, A. . Biotechnological Approach to Platinum-based Antitumor Research.  Drug Development through Biopharmaceutical Sciences, NRCT-JSPS Core University System Pharmaceutical Sciences.  10-13, Hat Yai, Songkla 90112, Thailand,  24-26 November, 1998
  22. Ratanaphan, A. . Site-Directed Mutagenesis to Study the Substrate Specificity of a Class C beta-Lactamase..  “Biotechnology: An Essential Tool for Future Development?”, .  145, Suranaree University of Technology, Nakhonratchasima, Thailand,  19-22 November , 1997
  23. Ratanaphan, A., Koop, R. and Holler, E.. Gel Shift Assay of Estrogen Receptor (ER) Binding to Platinated Estrogen Responsive DNA Element.  Analysis of Structure of Biomacromolecules and their Interactions with Environmental Cytotoxic Agents.  P21, Institute of Biophysics, Academy of Science of the Czech Republic, Brno, Czech Republic,  19-22 July, 1993
  24. Koop, R., Ratanaphan, A. and Holler, E.. Hormone-Regulated Expression of Reporter Gene in the Study of DNA-Platinum Lesions .  European Science Foundation Workshop: In Metal Ion Interactions with Nucleic Acids and their Constituents.  -, University of Dortmund, Haus Bommerholz/Witten, Germany,  29-1 March-April, 1993
  25. Ratanaphan, A. and Vatanatham, S.. Production of hydrofluoric acid from low grade fluorspar.  First mining symposium.  287-293, Department of Mining and Metallurgy, Faculty of Engineering, Prince of Songkla University, Songkla 90112, Thailand,  28-29 May, 1981
  ประเภทหนังสือและตำรา ::
  1. Ratanaphan, A. 2000, Pharmaceutical Biotechnology ,  - จำนวนหน้า 234
  2. Ratanaphan, A. and Mansa-ard, J. 2000, Spectroscopy : Instrumental Technique of Analysis ,  - จำนวนหน้า 259
  3. Ratanaphan, A.  1989, Spectrophotometry and Application to Pharmaceutical Analysis  ,  - จำนวนหน้า 140
  4. Ratanaphan, A.  1989, Laboratory Manual in Pharmaceutical Control III  ,  - จำนวนหน้า 125.
  5. Ratanaphan, A.  1985, Laboratory Manual in Pharmaceutical Control II  ,  - จำนวนหน้า 146
  งานวิชาการประเภทอื่นๆ (เช่น สิ่งประดิษฐ์ สิทธิบัตร ฯลฯ) ::